Small and medium-sized enterprises: Pål Nyrén
Winner of the European Inventor Award 2013 in the category SMEs
Adding a spark to DNA sequencing
A far faster, less complicated and less time-consuming method to sequence DNA strands that uses the photo-reactive properties of chemicals and DNA enzymes to identify DNA sequences.
Pyrosequencing AB, renamed to Biotage AB, acquired by Qiagen
The invention in a nutshell
Pyrosequencing is a DNA-sequencing technology invented and patented by Pål Nyrén. The technology surpassed existing DNA-sequencing procedures in terms of speed, efficiency and cost. It has been instrumental in driving down the cost of DNA sequencing while greatly increasing its speed and volume.
Pyrosequencing and related technological advances have driven down the cost of DNA sequencing, to a point where an entire genome can be sequenced for approximately US $8,000. The combined trend of lower costs and greater speeds has revolutionised the study of the building blocks of life, created new fields of study and is helping us understand hereditary diseases and other illnesses. This gives researchers new avenues for pursuing treatments and cures for life-threatening diseases such as cancer.
In 2008, the company Pål Nyrén co-founded to bring Pyrosequencing to market was acquired by the company Qiagen for US $53 million. The Pyrosequencing method was also licensed to 454 Life Sciences, which is now owned by the pharmaceuticals giant Roche.Presently, the sequencing instrument market generates annual revenues of US $1.6 billion, and is expected to grow to US $2.2 billion within the next four years.